Novel approaches to monitor and manipulate single neurons in vivo.

Michael Brecht,1 Michale S. Fee,2 Olga Garaschuk,3 Fritjof Helmchen,4 Troy W. Margrie,6 Karel Svoboda,7 and Pavel Osten5 1Department of Neuroscience, Erasmus Medical Center, University Medical Center Rotterdam, 3015 DR Rotterdam, The Netherlands, 2Department of Brain and Cognitive Sciences, McGovern Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, 3Institute of Physiology, LudwigMaximilians University Munich, 80336 Munich, Germany, Departments of 4Cell Physiology and 5Molecular Neurobiology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany, 6Department of Physiology, The Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, United Kingdom, and 7Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11743